Publications

Harrison Lab Publications of Note

Perform a customized PubMed literature search for Dr. Harrison.
• Schulz, K.N. and Harrison, M.M. (2018). Mechanisms regulating zygotic genome activation. Nat Rev Genet. 

• Hamm, D.C. and Harrison, M.M. (2018). Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster. Open Biol. 

• Dufourt, J., Trullo, A., Hunter, J., Fernandez, C., Lazaro, J., Dejean, M., Morales, L., Nait-Amer, S., Schulz, K.N., Harrison, M.M., Favard, C., Radulescu, O., and Lagha, M. (2018). Temporal control of gene expression by the pioneer factor Zelda through transient interaction hubs. Nat. Commun. 9: 5194.

• Bier, E., Harrison, M.M., O’Connor-Giles, K.M., and Wildonger, J. (2018). Advances in Engineering the Fly Genome with the CRISPR-Cas System. Genetics. 208(1): 1-18.

• Hamm, D.C., Larson, E.D., Nevil, M. Marshall, K.E., Bondra, E.R., and Harrison, M.M. (2017). A conserved maternal-specific repressive domain in Zelda revealed by Cas9-mediated mutagenesis in Drosophila melanogaster. PLoS Genet.e1007120

• Janssens, D. H., Hamm, D. C., Anhezini, L., Xiao, Q., Siller, K. H., Siegrist, S. E., Harrison, M.M., and Lee, C.-Y. (2017) An Hdac1/Rpd3-Poised Circuit Balances Continual Self-Renewal and Rapid Restriction of Developmental Potential during Asymmetric Stem Cell Division. Dev Cell. 40(4): 367–380.

• Nevil, M., Bondra, E. R., Schulz, K. N., Kaplan, T., and Harrison, M. M. (2017) Stable Binding of the Conserved Transcription Factor Grainy Head to Its Target Genes Throughout Drosophila melanogaster Development. Genetics. 205(2): 605-620.

• Schulz, K.N., Bondra, E.R., Moshe, A., Villalta, J.E., Lieb, J.D., Kaplan, T., McKay, D.J., and M.M. Harrison. (2015) Zelda is differentially required for chromatin accessibility, transcription-factor binding and gene in expression in the early Drosophila embryo. Genome Res. 25(11):1715-26.

• Harrison, M. M., & Eisen, M. B. (2015) Transcriptional Activation of the Zygotic Genome in Drosophila. Curr Top Dev Biol. 113: 85–112.

• Gratz, S.J., Rubinstein, D., Harrison, M.M., Wildonger, J., and K.M. O’Connor-Giles. (2015) CRISPR/Cas9- genome editing in Drosophila. Curr Protoc Mol Biol. 111: 31.2.1 – 31.2.20.

• Gratz, S.J., Harrison, M.M., Wildonger, J., and K.M. O’Connor-Giles. (2015) CRISPR/Cas9- genome editing in Drosophila. Methods Mol Biol. 1311: 335-348.

• Hamm, D.C., Bondra, E.R., and M.M. Harrison. (2015) Transcriptional Activation is a Conserved Feature of the Early Embryonic Factor Zelda that Requires a Cluster of Four Zinc Fingers for DNA binding and Low-Complexity Activation Domain. J Biol Chem. 259:3508-3518.

• Li, X.Y., Harrison, M.M., Villata, J.E., Kaplan, T.* , and M.B. Eisen*. (2014) Establishment of regions of genomic activity during the Drosophila maternal to zyotic transition. eLife 3: doi10.7554
*co-senior authors

• Harrison, M.M., Jenkins, B.V., O’Connor-Giles, K.M. and J. Wildonger. (2014) A CRISPR view of development. Genes Dev. 28:1859-1872.

• Gratz, S.J., Wildonger, J., Harrison, M.M., and K.M. O’Connor-Giles. (2013) CRISPR/Cas9-mediated genome engineering and the promise of designer flies on demand. Fly. 7:249-255.

• Gratz, S.J., Cummings, A.M., Nguyen, J.N., Hamm, D.C., Donohue, L.K., Harrison, M.M.*, Wildonger, J.* and K.M. O’Connor-Giles*. (2013) Genome engineering of Drosophila with the CRISPR RNA-guided Cas9-nuclease. Genetics. 194:1029-1035.
recommended by Faculty of 1000
* corresponding authors

• Harrison, M.M. *, Li, X.Y*. Kaplan, T. *, Botchan, M.R., and M.B. Eisen. (2011) Zelda Binding in the Early Drosophila melanogaster Embryo Marks Regions Subsequently Activated at the Maternal-to-Zygotic Transistion. PLoS Genet. 7:e1002266.
highlighted in Nature Reviews Genetics and recommended by Faculty of 1000
* contributed equally

• Tabuchi, T.M., Deplancke, B., Osato, N., Zhu, L.J., Barrasa, I.M., Harrison, M.M., Horvitz, H.R., Walhout, A.J. and K.A. Hagstrom. (2011) Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex. PLoS Genetics. 7:e1002074.

• Cline, T.W., Dorsett, M., Sun, S., Harrison, M.M., Dines, J., Sefton, L., and L. Megna. (2010) Evolution of the Drosophila feminizing switch gene Sex-lethal. Genetics. 186:1321-1336.

• Harrison, M.M., Botchan, M.R. and T.W. Cline. (2010) Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Dev Biol. 345: 248-255.

Pre 2010
• Harrison, M.M., Lu, X. and H.R. Horvitz. (2007) LIN-61, one of two Caenorhabditis elegans malignant-brain-tumor-repeat-containing proteins, acts with DRM and NuRD-like protein complexes in vulval development but not in certain other biological processes. Genetics. 176: 255-271.

• Harrison, M.M., Ceol, C.J., Lu, X., and H.R. Horvitiz. (2006) Some C. elegans class B synMuv proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex. Proc Natl Acad Sci USA. 103: 16782-16787.

• Ceol, C.J., Stegmeier, F., Harrison, M.M., and H.R. Horvitz. (2006) New classes of genes that act as negative regulators of let-60 Ras signaling in Caenorhabditis elegans. Genetics. 173: 709-726.

• Davison, E.M., Harrison, M.M., Walhout, A.J., Vidal, M., and H.R. Horvitiz. (2005) lin-8, which antagonizes Caenorhabditis elegans Ras-mediated vulval induction, encodes a novel nuclear protein that interacts with the LIN-35 Rb protein. Genetics. 171: 1017-1031.

• Sim, R.J., Harrison, M.M., Moxon, E.R., and C.M. Tang. (2000) Underestimation of meningococci in tonsillar tissue by nasopharyngeal swabbing. Lancet. 356: 1653-1654.