Welcome to the Harrison lab!

Research in the Harrison lab focuses on how information encoded in the genome is differentially interpreted during organismal development. Specifically, we study the molecular mechanisms regulating gene expression and how changes in gene expression can drive cell identity. Because these processes are highly conserved amongst metazoans, we leverage the wide number of tools available to study this regulation in the Drosophila embryo. Current research in the laboratory is primarily directed at understanding the function of two essential transcriptional regulators: Zelda and Grainyhead.

In our lab, we are committed to making science more equitable. We believe that the most innovative science happens within a diverse team and a supportive environment. To this end, we strive to eliminate systemic barriers to the recruitment and retention of underrepresented groups in science.

We are looking for folks to join the lab! Check this out for more information: Postdoc Posting

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News

• Congrats to Sam on his NOA for his F30 fellowship! Looking forward to more exciting science.

• We are so excited to welcome new grad student Meghan Freund to the lab! Can’t wait to see the great things to come.

Recent Publications

• Jain, S.U., Rashoff, A.Q., Krabbenhoft, S.D., Hoelper, D., Do, T.J., Gibson, T.J., Lundgren, S.M., Bondra, E.R., Deshmukh, S., Harutyunyan, A.S., Juretic, N., Jabado, N., Harrison, M.M., Lewis, P.W. (2020) H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2. Mol Cell. 80:726-735.

• Nevil, M., Gibson, T.J., Bartolutti, C., Ayengar, A., and Harrison, M.M. (2020). Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated. Development. 147:dev185009.  more publications…