The maternal-to-zygotic transition is conserved among metazoans.
Welcome to the Harrison lab!
Research in the Harrison lab focuses on how information encoded in the genome is differentially interpreted during organismal development. Specifically, we study the molecular mechanisms regulating gene expression and how changes in gene expression can drive cell identity. Because these processes are highly conserved amongst metazoans, we leverage the wide number of tools available to study this regulation in the Drosophila embryo. Current research in the laboratory is primarily directed at understanding the function of two essential transcriptional regulators: Zelda and Grainyhead.
• Our review on zygotic genome activation is out in Nature Reviews Genetics. Great to be a part of this fast-paced and exciting field.
• Excited that our review of the MZT in Drosophila is out in Open Biology.
• Schulz, K.N. and Harrison, M.M. (2018). Mechanisms regulating zygotic genome activation. Nat Rev Genet.
• Hamm, D.C. and Harrison, M.M. (2018). Regulatory principles governing the maternal-to-zygotic transition: insights from Drosophila melanogaster. Open Biology.