The maternal-to-zygotic transition is conserved among metazoans.
Welcome to the Harrison lab!
Research in the Harrison lab focuses on how information encoded in the genome is differentially interpreted during organismal development. Specifically, we study the molecular mechanisms regulating gene expression and how changes in gene expression can drive cell identity. Because these processes are highly conserved amongst metazoans, we leverage the wide number of tools available to study this regulation in the Drosophila embryo. Current research in the laboratory is primarily directed at understanding the function of two essential transcriptional regulators: Zelda and Grainyhead.
We are looking for folks to join the lab! Check this out for more information: Postdoc Posting
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• Our paper demonstrating the developmental regulation of the pioneer factor Grainy head was accepted at Development.
• The Harrison lab is “Looking Fly” in our profile in the UW Carbone Cancer Center newsletter. https://www.uwhealth.org/news/looking-fly/53042
• McDaniel, S.L., Hollatz, A.J., Branstad, A.M., Gaskill, M.M., Fox, C.A. and Harrison, M.M. (2020). Tissue-Specific DNA Replication Defects in Drosophila melanogaster Caused by a Meier-Gorlin Syndrome Mutation in Orc4. Genetics
• McDaniel, S.L., Gibson, T.J., Schulz, K.N., Fernandez Garcia, M., Nevil, M., Jain, S.U., Lewis, P.W., Zaret, K.S.and Harrison, M.M. (2019). Continued activity of the pioneer factor Zelda is required to drive zygotic genome activation. Mol Cell. more publications…